Before Apopka was "The Indoor Foliage Capital of the World" or even before it was "The Fern City," it was The Lodge. From about 7500 B.C. until about the 1st century A. D. when they disappeared for reasons unknown, Indians were believed to have lodged on the shores of Lake Apopka. Then for about 400 years the region appears to have been uninhabited.

When the Spaniards arrived in Florida in the 16th century, the Acuera tribe of the Timucua confederation was said to have lived in the Apopka area, growing crops and trading. By 1730 these natives were decimated by war and diseases brought by the Europeans and had also disappeared.

Then early in the 19th century, Indians again inhabited the area. There was a Seminole village on Lake Apopka, or Ahapopka, as they spelled and pronounced it. It remained an active village until the outbreak of the Second Seminole War in the mid 1830s. Coacoochee (Wild Cat), one of the most famous and influential War Chiefs, was born here and ruled as Chief of about 200 Indians until this village was evacuated and the natives sought refuge in the swampy areas around the St Johns.

The Armed Occupation Act of 1842 brought white settlers to the Apopka area. They received 160 acres if they would settle them.  These Pioneers and those that followed the Civil War from states to the north began converting the area into what it is today.

The settlement grew, attracting developers and settlers because of the climate and the agricultural opportunities and becoming an important trading center in the 1850s. The Masons' were particularly active. Orange Lodge #36 was organized in 1857, and The Lodge building, still standing on its original site at Alabama Avenue and Highway 441, was completed in 1859.

It was around this building that the town grew in the 1860s and 1870s and ultimately became the Town of Apopka City incorporated in 1882.